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GENERAL INFORMATION ON CLINICAL TRIALS
Consumer Health Forum clinical trials project
The Consumer Health Forum (CHF) was funded by the Department of Innovation, Industry, Science and Research to develop a factsheet to provide consumer-friendly information about clinical trials, in response to a recommendation for improved consumer access to information on clinical trials. CHF members were engaged in focus testing and many provided input into the content and development of the factsheet.
The factsheet is available online, in both colour and print-friendly versions. You can access it on the Consumer Health Forum website: https://www.chf.org.au/clinical-trials-project.php
Please feel free to distribute the link and the factsheet broadly to family, friends and consumer networks.
Clinical Trials Connect
CTC is recognised by the National Health and Medical Research Council (NHMRC) and the Federal Government Department of Innovation Industry Science Research and Tertiary Education (DIISRTE). CTC is also listed as one of two portals most relevant to Australian consumers currently in the Consumer Health Forum 'Guide to Clinical Trials' factsheet, and has recently been listed on the new Government website Australian Clinical Trials.
For more information about Clinical Trials Connect visit the website: www.ctc.asn.au
Australian Clinical Trials
CURRENT CLINICAL TRIALS
Fast Vs slow weight loss - which is better? The TEMPO Diet Trial (09/02/2016)
Losing excess weight is scientifically proven to help reduce and prevent joint pain. One way to get support for weight loss is to participate in a clinical weight loss trial, where you get the support of a research team and others in the trial.
For many years health professionals have recommended ‘slow and steady’ weight losses of approximately 0.1 to 1 kilo per week. In recent years however, an increasing number of health professionals are prescribing meal replacement diets called very low calorie diets (VLCDs) because they can induce relatively fast weight losses of approximately 0.5 to 2 kilos per week, which some people find motivating, and because some people report not feeling hungry while following a VLCD.
While VLCDs are known to be safe and effective in the short-term (for up to one year), the long-term consequences are unknown. This study will demonstrate whether or not there is any difference between the effects of weight loss via VLCD or conventional diet on metabolic health, body fat content and distribution, muscle mass and strength, and bone density in post-menopausal women for 3 years after commencement of the diet.
To watch Associate Professor Amanda Salis talking about the TEMPO Diet Trial click here.
To watch Associate Professor Amanda Salis talking about A Day in the Life on a VLCD, click here.
To read the Information for Participants click here (PDF file).
Recruitment for the TEMPO Diet Trial is currently underway. If you are interested in participating in this trial and are female, living in the Sydney metropolitan area, aged 45-65, postmenopausal for 5 years or more, are non-diabetic and you have a body mass index (BMI*) of 30 to 40 kg/m2, you may be eligible for this study.
*To calculate your BMI, divide your weight in kilograms by the square of your height in meters, or use this web-based BMI calculator: http://www.heartfoundation.org.au/healthy-eating/Pages/bmi-calculator.aspx.
What osteoarthritis treatment is best for you? (06/11/2015)
If you have knee and/or hip osteoarthritis (OA), the process of deciding on a treatment can be difficult.
The University of Sydney is conducting reserach to see what helps people with hip or knee OA by conducting a research project on decision aids.
A 'decision aid' is a tool to help you understand what your treatment options are and what is important to you in deciding among the various options.
The main purpose of this study is to evaluate the usefulness of the decision aid for people with osteoarthritis and to see if there is a change in the quality of decisions after using having used it.
Read more and do the survey here: http://healthbook.health.usyd.edu.au/index.php?PageID=survey_respond&SurveyID=1143
Allow about 30 minutes to complete the survey and to find out what OA treatments are best for you.
Are you living with an ongoing upper limb condition that affects your sex life? (06/11/2015)
A satisfying sex life is important for well-being and quality of life. Ongoing upper limb conditions can have a profound effect on participation in sexual activities. However, sexual concerns are often ignored by health care professionals due to lack of knowledge. This study at Charles Sturt University aims to gain an insight into how upper limb conditions impact couples’ sex lives, how they adapt to any difficulties, and what type of information or assistance they want from health care professionals. A final outcome of the project will be the compilation of a fact sheet about upper limb conditions and sexual activity, which could be useful to both health care professionals and other people with ongoing upper limb conditions.
Participants should be:
Participants would also need to be prepared to be interviewed about their experiences.
For more information click here or contact Miranda Schroeder on:
Phone: 02 6051 9225
CUBA – Cane for Knee Pain Study (02/11/2015)
Then the CUBA – Cane for Knee Pain Study may be for you. The University of Melbourne (Parkville) and Royal North Shore Hospital Sydney (St Leonards) are investigating the effect of daily walking with a cane for 12 weeks on knee osteoarthritis, pain and physical function.
If you are interested in participating or would like more information, please visit the study website http://cubastudy.info or contact Charlotte on:
Phone: 03 8344 0485
Help needed for online Pain Research Survey (29/09/2015)
This is a brief online survey to help close the gap in our understanding of pain.
You are likely eligible if you over 18 and suffer from rheumatoid arthritis, fibromyalgia, migraines, neck pain, whiplash or low back pain (will take only 15-minutes). If you have no current pain or history of persistent pain (a pain problem that lasted more than 3 months) then you are also eligible to take the survey as a control subject (takes 5-minutes only).
Please follow this link to the survey: https://prodsurvey.rcs.griffith.edu.au/prodls190/index.php?sid=29267&lang=en
For more information contact Daniel at Griffith University:
Do you suffer from fibromyalgia? (22/7/15)
The Monash Alfred Psychiatry Research Centre (MAPrc) at the Alfred Hospital campus is currently seeking volunteers for a clinical trial of a non-medication investigational treatment for fibromyalgia called repetitive Transcranial Magnetic Stimulation (rTMS).
rTMS is a painless, safe, and non-invasive means of stimulating nerve cells in the brain. We are conducting this study to see whether we can reduce the symptoms associated with fibromyalgia.
Participants should be located in Melbourne and be:
Participation will involve attending MAPrc for 20 rTMS treatments over a four week period. Each treatment takes approximately 30 minutes.
For more information click here or contact Dr Bernadette Fitzgibbon:
Phone: 03 9076 9860
STEP Trial - Safety, Tolerability and Efficacy of Progenza for osteoarthritis (21/7/15)
The STEP trial is a randomised phase 1 clinical trial, investigating the safety and efficacy of a stem cell therapy (Progenza) for knee osteoarthritis. It will compare stem cells to placebo, looking at safety, pain, function and cartilage loss in participants.
Study participants need to be located in Sydney and be:
For more information click here or contact Carolyn:
Phone: 0434 292 110
Melbourne - Knee Osteoarthritis Pain study (17/7/2015)
This study is a randomised clinical trial, investigating a new medication for knee pain in adults with osteoarthritis. We will compare amitriptyline 25mg tablets with a placebo, looking at knee-pain and its effect on daily life over a 12-week period. If effective, this medication will offer a new way to manage pain for people with knee osteoarthritis.
Participants should be located in Melbourne and be:
For more information contact Cameron, Molly, or Clare:
Phone: 03 9903 0553
Rheumatoid Arthritis: Make It A Family Affair (21/5/15)
The University of Queensland’s Diamantina Institute is investigating the prevention of rheumatoid arthritis before symptom onset.
Did you know that if you have rheumatoid arthritis, your family could be at greater risk of developing the disease at some point in their life?
Help them better understand how to prevent the development of rheumatoid arthritis in your loved ones by taking part in this study
Study participants need to be located in Brisbane and can be:
· Rheumatoid arthritis patients
· Their first degree relatives
· Healthy adults without rheumatoid arthritis
For more information, click here or contact Amelie:
Phone: (07) 3443 6992
Internet-based Hip OsteoArthritis Pain Exacerbation (iHOAP) Study (26/03/15)
Do you have hip osteoarthritis diagnosed on an x-rayand have access to that x-ray?
Are you over 40 years old?
Do you experience hip pain on most days that fluctuates?
If so, you are invited to take part in an online study to help researchers determine the factors that influence your level of hip pain (e.g. weather, physical activity, foot-wear, hip injury, etc.).
FREE treatment to improve wellbeing for people 65 years or over with arthritis (22/08/14)
The University of Sydney and beyondblue are jointly conducting a study aimed at all persons aged 65 years and over.
We are interested in how chronic illnesses, such as arthritis, affect older adults’ wellbeing. Persons who report at least one chronic illness may be eligible for the chance to receive 10 FREE sessions of psychological therapy with a registered psychologist, or a FREE online course to maintain wellbeing.
All persons aged 65 years or over are eligible to complete a 5-minute survey. Click here to complete the questionnaire.
Or contact Lauren Roche for a paper version of the survey:
Phone: 02 9351 4257
Do you suffer painful knee osteoarthritis? (28/07/14)
Specialists from Royal North Shore Hospital, St Leonards are conducting a six month research study that will observe whether different types of hyaluronic acid/steroid combination knee injection therapies can reduce pain severity in knee osteoarthritis patients.
You may be eligible if you are: between 40 and 85 years old, have mild to moderate knee pain due to osteoarthritis and taking pain mediation on most days.
All participants will receive one of three potential treatments: our investigational products, hyaluronic acid or steroid combination, or a frequently used product for management of knee osteoarthritis.
Participants will be reimbursed for travel and some out of pocket study related expenses.
For further detail click here.
For details of other participating sites in Australia, click here.
Or further information contact:
Phone: 02 9463 1774
Do you have painful osteoarthritis in your knees? (9/4/14)
Some people with arthritis have great difficulty controlling their pain with usual medications. This may be because their pain is different. This study is investigating whether a different type of medication may be more effective for these people.
Researchers from Curtin University and Royal Perth Hospital are looking for volunteers to participate in a 4-week study, investigating the effects of a neuropathic pain medication on pain sensitivity, movement and quality of life in people with painful osteoarthritis of the knee. It would involve you taking pills for 28 days and attending 3 sessions for sensory and physical tests.
NOTE: Study is being undertaken only in PERTH, WA.
Research study to investigate how the brain effects the way muscles around the knee work (05/03/14)
If you have been diagnosed with knee osteoarthritis, you are invited to participate in a study to investigate how the brain effects the way muscles around the knee work.
All procedures are non-invasive and pain-free and conducted at University of Western Sydney, Campbelltown campus.
For more information about the study click here or contact Abrahao Baptista at
Personality style and Arthritis on overall health and wellbeing (03/03/14)
If you have been diagnosed with Rheumatoid Arthritis or Osteoarthritis, you are invited to participate in a study designed to investigate the combined impact of personality and chronic illness on general health and functioning. The study involves completion of a online survey, with questions relating to symptoms, social support, health behaviour and personality. To access the survey directly, visit https://www.deakin.edu.au/psychology/research/clinical_study.
Email: Sharon Horwood or Daniel at
Low back pain PREVENT study - Participants needed (03/02/14)
Are you currently suffering an acute (less than 4 weeks) episode of low back pain?
You are invited to participate in an NHMRC research project – the PREVENT study - which aims to help people recover early from their low back pain.
To participate, you will meet with a pain clinician at Neuroscience Research Australia (NeuRA), Barker Street, Randwick 2031, for an examination and two one-hour consultations. This service is completely free to you.
Contact: Dr Markus Huebscher
T: 02 9399 1049
Reviewed and updated February 2016
Past Clinical Trials