IV Immunuglobulin

What is IV Immunoglobulin

Intravenous immunoglobulin (IVIg) is a mixture of blood proteins called antibodies that are made by the immune system to fight infections. Immunoglobulins are extracted from healthy donated blood and are used to treat a number of medical conditions. IVIg is given to patients as an intravenous infusion.

How doses IVIg work?

In some medical conditions the body’s immune system becomes overactive and starts attacking a person’s own body tissues, such as nerves, muscle or skin. IVIg is given to patients with these inflammatory conditions to reduce and alter the immune systems response.

For which medical conditions is IVIg used?

IVIg has been shown to be beneficial in many medical conditions including certain inflammatory disorders and to treat patients who do not have sufficient antibodies.
Some examples of conditions where IVIg may be used:

  • Inflammatory myopathy, such as polymyositis and dermatomyositis;
  • Myasthenia gravis;
  • Multifocal motor neuropathy;
  • Kawasaki disease (a disease which results in multiple inflammations of several organs);
  • Guillian Barré syndrome (a disease with multiple inflammations of the nervous system of the whole body;
  • Lambert-Eaton myaesthenic syndrome (an autoimmune disorder causing muscle weakness in the arms and legs).

The above list of conditions are just some examples of the many medical conditions in which IVIg may be used. Ask your doctor if you have questions about the use of IVIg in your particular condition.

How is IVIg given?

IVIg is given as an intravenous (into a vein) infusion. At the beginning of the treatment, the infusion (the drip) will be set at a slow rate. Depending upon how comfortable you are, your doctor may then gradually increase the infusion rate.

How much IVIg is given?

Your doctor will decide how much IVIg will be given to you. The dosage will vary depending on your condition and how much you weigh. The dosage may vary for different individuals. You may receive a different dose at each visit depending upon your condition.

Ask your doctor if you have questions about your dose of IVIg.

How many times will I be given IVIg?

Your doctor will review your condition after your IVIg treatment and will decide if you need further doses.

Are there any side effects?

You might experience side effects with your treatment. Tell your doctor as soon as possible if you do not feel well while you are receiving treatment with IVIg.

Most common possible side effects

  • The following reactions may occur at the site of the infusion (where the drip is put into your vein): redness, warmth, itching, swelling, mild or moderate pain, or bruising.
  • Other common side effects that may occur during your IVIg infusion: headache, migraine, chills, mild fever, tiredness, weakness, nausea, rash, increased heart rate, abdominal pain, dizziness or increased blood pressure.

Less common or rare possible side effects

Tell your doctor as soon as possible if you notice any of the following:

  • Fever or other signs of infection;
  • Chest pain or breathing problems;
  • Night sweats;
  • Reduced urination, sudden weight gain, or swelling in your legs. This could be signs of a kidney problem;
  • Brown or red urine, fast heart rate, yellow skin or eyes. These could be signs of a liver problem or a blood problem.

If any of the following happen, tell your doctor immediately or go to the Accident & Emergency at your nearest hospital:

  • Hives, swelling in the mouth or throat, itching, trouble breathing, wheezing, fainting or dizziness. These could be signs of a serious allergic reaction.
  • Bad headache with nausea, vomiting, stiff neck, fever and sensitivity to light. These could be signs of irritation of the lining around your brain.
  • Pain, swelling, warmth, redness or a lump in your legs or arms. These could be signs of a blood clot.
  • Chest pain or trouble breathing, blue lips or extremities. These could be signs of a serious heart or lung problem.

Tell your doctor or pharmacist immediately if any of side effects you experience get worse, or if you notice any side effects not listed in this leaflet.

There are some differences in the rate of certain side effects between brands of IVIg. This is because different brands of IVIg may have different salt or sugar content, or may have other different excipients (additives).

Because IVIg is extracted from donated blood, it undergoes vigorous testing to check for possible viruses. There are additional procedures in the manufacturing to reduce the possible risk of viruses. Despite these stringent measures during the manufacturing process, the risk of contamination by viral and other unknown agents cannot be completely eliminated.

Use with other medicines

  • You must tell your doctor if you are planning to get any vaccinations. IVIg may impair the effects of some live virus vaccines such as measles, mumps, rubella and varicella.

Use in pregnancy & breastfeeding

  • You should tell your rheumatologist if you are pregnant, planning to become pregnant or if you are breastfeeding.
  • Your doctor will consider the benefits and risks of using IVIg for your particular medical condition, if you are pregnant or breastfeeding.

Important things to remember

  • If you are worried about any possible side effects you should contact your rheumatologist as soon as possible.

For more information see the IV Immunuglobulin – printable information sheet.

This Information Sheet has been prepared using materials obtained from various sources which have been reviewed by the Australian Rheumatology Association (ARA). It contains general information only and does not contain a complete or definitive statement of all possible uses, actions, precautions, side effects or interactions of the medicines referenced. This information is not intended as medical advice for individual conditions nor for making an individual assessment of the risks and benefits of taking a particular medicine. Decisions regarding the assessment and treatment of patients are the sole responsibility of the treating medical professional, exercising their own clinical judgment and taking into account all of the circumstances and the medical history of the individual patient. ARA has used all reasonable endeavours to ensure the information on which this Information Sheet is based is accurate and up to date. However, the ARA accepts no responsibility or liability for the accuracy, currency, reliability and/or completeness of the information contained in this Information Sheet.  To the maximum extent permitted by law, the ARA expressly disclaims any liability for any injury, loss, harm or damage arising from or in connection with use of and reliance on the information contained in this Information Sheet. This information sheet is copyright and may be reproduced in its entirety but may not be altered without prior written permission from the ARA.Page updated October 2023