Glucosamine for the Treatment of Osteoarthritis
Australian Rheumatology Association and Arthritis Australia Statement regarding the use of glucosamine for the treatment of Osteoarthritis
Recent media reports have raised concern over the use of glucosamine in the treatment of osteoarthritis. These reports appear to be based on two unrelated recent events:
1. A change in recommendation by the American College of Rheumatology (ACR) 
In October 2019 the ACR updated their guidelines for the management of osteoarthritis from a longstanding conditional recommendation against the use of glucosamine for osteoarthritis (on the basis that it probably does not help), to a strong recommendation against the use of glucosamine for osteoarthritis (on the basis that it convincingly does not help). They did not cite new safety concerns.
2. A recent paper highlighting the known risks associated with glucosamine, particularly in people with shellfish allergy 
This paper reviewed 366 glucosamine related adverse drug reactions reported to the Therapeutic Goods Administration between 2000-2011, including 43 classified as severe, possibly related to the known risks of glucosamine in those with shellfish allergy. This highlights a valid concern but the number of adverse events needs to be considered in the context of the many hundreds of thousands of people who took glucosamine during that period. This suggests that severe adverse reactions are very uncommon.
Many other osteoarthritis treatment guidelines make conditional recommendations against the use of glucosamine on the basis that it probably does not help, including The Royal Australian College of General Practitioners guideline for the management knee and hip OA .
Arthritis Australia and Australian Rheumatology Association comment:
This information highlights growing evidence that glucosamine does not help people with osteoarthritis and is a reminder that people with shellfish allergy should not take glucosamine (which is commonly derived from shellfish). It does not identify any new safety concerns and should not cause undue alarm in people already taking glucosamine.
Comment from The Royal Australian College of General Practitioners (RACGP):
Dr Harry Nespolon, President of the RACGP stated “The RACGP does not recommend the use of glucosamine as a way of preventing osteoarthritis. If you have concerns about using glucosamine or treatment for osteoarthritis I recommend you have a chat with your local GP about the options available to you.”
Australian Rheumatology Association – T: 02 9252 2356 E: [email protected]
Arthritis Australia – T: 02 9518 4441 E: [email protected]
The Royal Australian College of General Practitioners – T: 03 8699 0939 | E: [email protected]
Stem cell therapy for osteoarthritis
- Stem cell therapies offer great promise as a potential treatment strategy for a range of conditions, including osteoarthritis.
- However, research is still in its early stages and so far there is not enough high quality evidence to know whether these therapies are safe and effective for osteoarthritis.
- Clinically unproven stem cell therapies may pose serious risks to your health. These risks include infection, ectopic tissue formation (growth of body tissues in the wrong place) and allergies.
- Some clinics in Australia and overseas are marketing unproven stem cell therapies for osteoarthritis directly to consumers. Changes will soon be introduced to improve regulatory oversight of these therapies and to prohibit advertising of unproven stem cell therapies directly to consumers in Australia.[i]
- Ongoing, high-quality research through properly regulated clinical trials is required to determine what role, if any, stem cell therapies may play in the treatment of osteoarthritis.
Osteoarthritis is a leading cause of pain and disability in the Australian population. It affects two million people and costs the health system at least $2 billion a year. With an ageing and increasingly obese population, the prevalence of osteoarthritis is expected to increase to 5.5 million people by 2030.
Currently, there are no disease-modifying therapies with a credible evidence base for osteoarthritis. Hence there is a pressing need for quality research into potential new treatments for the condition.
Autologous stem cell therapies offer promise as a potential treatment for osteoarthritis. These therapies for osteoarthritis usually involve the collection of a patient’s own fat cells which are then purified, stimulated and re-injected into an osteoarthritic joint.
However, at present there is not enough evidence to support the use of these stem cell therapies for osteoarthritis. Current research is still in its early stages and understanding of how effective and safe these therapies are is limited. Further research, through properly conducted randomised controlled clinical trials, is essential to determine the therapeutic role of stem cell treatments for osteoarthritis.
Some clinics in Australia are marketing these unproven autologous fat-derived stem cell therapies for osteoarthritis directly to consumers, despite the lack of sufficient evidence of benefit and safety. These treatments are often provided at substantial financial costs to consumers, including treatment and follow-up costs, as well as the potential cost of emergency medical care in the event of medical complications.
The Therapeutic Goods Administration, which is responsible for regulating therapeutic goods in Australia, will soon be introducing changes to increase regulatory oversight of stem cell therapies and prohibit advertising of unproven stem cell therapies directly to consumers.i Arthritis Australia strongly supports these changes.
Arthritis and Exercise - The Essentials
Both in Australia and worldwide, osteoarthritis and rheumatoid arthritis are major causes of disability and chronic pain. Research has established exercise as a safe and recommended treatment for these arthritides. Despite evidence and clinical guidelines, both consumers and health practitioners report confusion and uncertainty around the prescription of, and participation in, exercise.
The purpose of this paper is to provide clear, evidence-based practical recommendations about the role of exercise in the management of osteoarthritis and rheumatoid arthritis as a guide for consumers, health professionals and exercise & fitness professionals. These recommendations will also underpin the development of criteria that can be used to evaluate whether current and proposed community exercise programs are suitable for people with these arthritides.
Arthritis Australia established an expert advisory panel to guide the process. A narrative review of current literature was conducted, focusing on Cochrane and systematic reviews including meta-analysis of results available up to April 2014. The paper was drafted by members of the Arthritis Australia’s Expert Advisory Panel, and reviewed and revised by all panel members until consensus was reached. Arthritis Australia’s Board, Scientific Advisory Committee and Affiliate Healthy Lifestyle Coordinators all reviewed the paper and provided further input.
Five core components of effective exercise programs were identified and explored: assessment; education; exercise prescription; monitoring and reporting; and behaviour change strategies. Evidence for each was reviewed, summarised and practical recommendations made.
Substantial evidence supports the key role of exercise in the successful management of osteoarthritis and rheumatoid arthritis. By compiling evidence-based recommendations on exercise for these forms of arthritis, this document provides a national resource for consumers, health professionals and exercise and fitness professionals to guide exercise prescription and evaluate whether current and proposed community exercise programs are suitable for people with arthritis.
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