Partnering for progress – Reset rheumatoid arthritis

Through this support from the Australian Government, Arthritis Australia and people living with rheumatoid arthritis are central to guiding this ground-breaking Australian research.

What is RESET RA?

This study is exploring a completely new approach to rheumatoid arthritis, providing targeted treatment early to help prevent it from becoming a long-term condition. The treatment is called antigen-specific immune tolerising immunotherapy.

This new approach aims to use targeted immunotherapy to ‘reset’ the immune system, aiming to switch off the cause of inflammation so the arthritis does not return.

Is this treatment ready for use?
While initial progress is highly promising, this pioneering treatment is still under advanced development and is not yet ready for routine clinical use. Progress is nevertheless continuing rapidly, supported by the Australian Government, through a Medical Research Future Fund Frontiers Grant. As part of this work, we are understanding more about how rheumatoid arthritis works.

Early stage clinical trials are expected to start in the second half of 2026.