Goserelin Acetate

What is Goserelin?

Goserelin belongs to a group of medicines called ‘GnRH agonists.’ In women, Goserelin works by reducing the amount of ‘oestrogen’ (a hormone) that is produced by your body.

Follow all directions given to you by your doctor carefully. They may differ from the information contained in this leaflet.

What benefit can you expect from your treatment?

You have been prescribed this medication to help protect and preserve your fertility for the future.

How is Goserelin used?

The Goserelin 3.6 mg Implant will be injected under the skin on your stomach every four weeks (28 days). This will be done by your doctor or nurse.

The implant is a very small pellet that is given by a special needle and syringe known as SafeSystem. The injection will not hurt very much.

The pellet is designed to slowly release the medicine into your body over four weeks.

When should it be used?

In women of child-bearing age, the first injection is injected during menstruation or shortly afterwards to exclude pregnancy. Use non-hormonal methods of contraception to avoid unwanted pregnancy, for example, in the event of missed doses.

Following doses are injected every 4 weeks for a 6 month course.

Can other medicines be taken with Goserelin?

Tell your doctor if you are taking any other medicines, including

  • tablets or supplements that you buy at the chemist, supermarket or health food shop.
  • oral contraceptives – they interfere with the way it works.

Your doctor or pharmacist can tell you what to do if you are taking any other medicines

How long is the treatment continued?

Treatment with Goserelin is continued for 6 months as long as no serious side effects occur.

Are there any side effects?

You might experience side effects with your treatment. Tell your doctor if you are concerned about possible side effects.

Most common possible side effects

  • Temporary increase in blood pressure
  • Hot flushes and sweating
  • Reduced sex drive
  • Pain, bruising, bleeding, redness or swelling where Zoladex is injected.

Less common or rare possible side effects

  • Breast tenderness & change in breast size
  • Dizziness and/or feeling faint
  • Headache
  • Mood swings
  • Allergic reactions (rash, itchiness, swelling of the face, lips or tongue, shortness of breath)
  • Low blood pressure

What precautions are necessary?

Goserelin may reduce bone mineral density. This was associated with an increased risk of fractures in men with prostate cancer. It is unclear whether the risk of fractures in premenopausal women is increased.

There have been small increases in risk for diabetes, heart attack and stroke reported. Your doctor will advise on any additional monitoring and dose adjustment of current medications may be necessary.

How to store Goserelin

  • Keep your Goserelin implant in the package until you take it to the doctor or nurse to give it to you. If you take the medication out of the pack you may dislodge the pellet in the syringe.
  • It should be kept in a cool, dry place where the temperature stays below 25°C. Do not store it or any other medicine in the bathroom or near a sink. Heat and dampness can destroy some medicines.
  • Keep it where young children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
  • Do not leave it in the car on hot days.
  • Do not use this medicine after the expiry date which is stated on the carton. The expiry date refers to the last day of that month.

For more information see the Goserelin Acetate- printable information sheet.

This Information Sheet has been prepared using materials obtained from various sources which have been reviewed by the Australian Rheumatology Association (ARA). It contains general information only and does not contain a complete or definitive statement of all possible uses, actions, precautions, side effects or interactions of the medicines referenced. This information is not intended as medical advice for individual conditions nor for making an individual assessment of the risks and benefits of taking a particular medicine. Decisions regarding the assessment and treatment of patients are the sole responsibility of the treating medical professional, exercising their own clinical judgment and taking into account all of the circumstances and the medical history of the individual patient. ARA has used all reasonable endeavours to ensure the information on which this Information Sheet is based is accurate and up to date. However, the ARA accepts no responsibility or liability for the accuracy, currency, reliability and/or completeness of the information contained in this Information Sheet.  To the maximum extent permitted by law, the ARA expressly disclaims any liability for any injury, loss, harm or damage arising from or in connection with use of and reliance on the information contained in this Information Sheet. This information sheet is copyright and may be reproduced in its entirety but may not be altered without prior written permission from the ARA. Page updated October 2023